Low Testosterone, Diabetes and Heart Disease

Low Testosterone or low t has been linked to several diseases that raise the likelihood of a shorter lifespan. Studies and clinical trials have come out recently from the United States, (St. Louis University, Duke University,) and the United Kingdom, (the Center for Men's Health, Barnsley Hospital,) indicate that men with low t may be more at risk for mortality associated with type 2 diabetes and coronary disease. Reports on some of the findings were published by Heart, a medical journal from BMJ Publishing.

First of all, the numbers of men who have low testosterone may be a staggering twenty-five to twenty percent, especially if they have been diagnosed with heart disease. This is surprising, because the previously estimated number of men with low t was twelve percent. This research comes from Duke University, who tracked 930 men. All of these men were diagnosed with coronary artery disease, which occurs when plaque builds up in the arteries that feed blood to and from the heart. This is also known as coronary heart disease. 930 men provided a good basis to study heart disease, but what the researchers discovered when they measured bio-available testosterone and took total testosterone levels (bio-t and TT,) was that one in every four patients also had low testosterone. What is even more striking about these numbers is that forty-two percent of the men with both coronary artery disease and low testosterone died during the study.

This is an estimated one of every eight men or twelve percent who died during the tests. The researchers at Duke are now trying to find out if plaque in the arteries or coronary artery disease affects low testosterone treatments and therapies.

If you are particularly aggressive and love to take risks, you can also blame high testosterone levels. But, surprisingly, you can also blame low t levels as well.

The researchers at Duke did further studies on both high and low testosterone levels in both men and women, and the effects this could have on certain personality traits, specifically aggression and risk taking. Their results were written up in the Psychological Science Journal. For this study 298 people were recruited and put through a battery of psychological studies. The tests were based on reward systems, where for "correct choices" the rewards fell into high, medium and low risk categories.

Those volunteers that fell in the extreme high and low ranges of testosterone levels showed an increased tendency for risk taking and aggression. While high testosterone levels have been linked to aggression, especially crimes of aggression, this was the first time that a study showed that low levels of testosterone could lead to the same behavior.

The researchers studied both men and women and the relationship to risk taking to high and low t levels was pretty much the same across the sexes.

St. Louis University did a study on low testosterone and Alzheimer's disease. According to their results, low t can lead to an increased risk of developing Alzheimer’s.

Researchers in the United Kingdom, have also been looking at low t. While both the US and the UK have been looking at new products for the treatment of low testosterone, researchers in London have been looking at low t statistics and the proportion of men with low t levels. Dr. Malcolm Carruthers, Director of London's Center for Men's Health states that twenty percent of the men in the United Kingdom have low testosterone.

In his statement to the Daily Express, he says, "It's astounding that this most common hormonal disturbance in men, which can wreck their lives is the least commonly treated."

Clinical trials held UK's ProStrakan looked at heart disease, type 2 diabetes, insulin resistance and low testosterone. Their research overlapped and confirmed some of the Duke research on heart disease. Treatment for low testosterone levels can in some cases lower the risk of heart disease and lower insulin resistence. It been effective even on men who are undergoing treatment for type 2 diabetes.

Dr. T. Hugh Jones and his researchers from Barnsley Hospital wrapped up their findings in the Diabetes Care journal. They found the metabolic syndrome of insulin resistance was positively affected by testosterone treatment.

However, their finding came with the caveat that blood sugar levels were ultimately not affected by testosterone treatment and controlling blood sugar is the Holy Grail for type 2 diabetes management.
 
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